Treatment with Y-27632, a ROCK Inhibitor, Increases the Proinvasive Nature of SW620 Cells on 3D Collagen Type 1 Matrix
Figure 4
SW620 cells were seeded at densities of 50 × 103 and 250 × 103 cells/cm2 onto 1.5 mg/mL collagen I gels. Scaffolds were treated with Y-27632 to study the impact of ROCK inhibition on cell invasion in a low- and high-density environment. Treatment with Y-27632 resulted in a 3.5-fold increase in cell invasion for cells seeded at 50 × 103 cells/cm2.
