S-Glutathionylation of Protein Disulfide Isomerase Regulates Estrogen Receptor Stability and Function
Figure 5
PDI expression levels affect PABA/NO-stimulated ERα degradation. (a) shows fluorescent images detailing similar subcellular distribution of PDI in normal and transfected cells. (b) shows Western blots of vector or PDI-transfected cells treated with PABA/NO for various times. In the transfected cells, over-expression of PDI stabilized intracellular ERα levels, preventing PABA/NO-induced S-glutathionylation from causing Erα degradation.
