Turnover of Focal Adhesions and Cancer Cell Migration

<table>Integrin-mediated cell adhesion to the ECM. (a) Suspended cells adhere to the surface of ECM via integrins. Some of the nascent adhesion contacts grow and form mature focal adhesions (FAs). (b) Integrins function as a heterodimer composed of <i>α</i>- and <i>β</i>-chains. (c) The cytoplasmic portions of integrins recruit multiple cellular proteins and form cross-linked platforms to regulate both the actin cytoskeleton and signal transduction.</table>

International Journal of Cell Biology

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Figure 1

Figure 1: Turnover of Focal Adhesions and Cancer Cell Migration 