The Many Faces of Mitochondrial Autophagy: Making Sense of Contrasting Observations in Recent Research

Table 2

Contrasting observations in yeast mitophagy research.

Observation	Supporting studies	Contradicting studies
Depolarisation triggers mitophagy	[51, 52]	[55]
Fission precedes mitophagy	[52]	[55]
Mitophagy by microautophagy (micromitophagy)	[42]
Stress and regulation of mitophagy
-TOR	[41, 55]
-MAPK	[54]
-Redox	[53]
-RTG	[44]	[45, 48]*
-General stress	[55]
-pH		[63]
Proteins required for mitophagy
-Uth1p	[41, 42]	[45, 48]*
-Aup1p	[43]	[45, 48]*
-Atg32p	[45, 48]
-Atg33p	[48]
Requirement of nonrespiratory medium to induce mitophagy under N-starvation	[38, 48]^†	[42, 52, 97]

*These studies reported no evidence of involvement, but did not directly contradict the observation.
^†In this study, limited mitophagy is demonstrated during lactate-supplemented N-starvation.