Synergistic Modulation of Cellular Contractility by Mixed Extracellular Matrices
Figure 5
ECM density-dependent deadhesion dynamics of MDA-MB-231 cells on collagen and fibronectin-coated substrates. ((a), (b)) Box whisker plots of time constants of retraction ( and ) on coverslips coated with collagen and fibronectin at varying densities. Faster deadhesion was observed at higher coating densities for both the ECM proteins. Bars indicate statistical significance (). (c) The net movement of the cell centroid during the deadhesion process was quantified for individual conditions. Centroid movement remained constant for all the conditions except on the 10 μg/cm2 collagen-coated surfaces where it was significantly higher ().
