Potential Role of Drebrin A, an F-Actin Binding Protein, in Reactive Synaptic Plasticity after Pilocarpine-Induced Seizures: Functional Implications in Epilepsy
Figure 3
Comparison of immunohistochemical labeling for drebrin A in hippocampal formation from control (Ctl; (a)) and pilocarpine-treated animals at 1 week (b), 2 weeks (c), and 12 weeks (d). The major difference compared to Ctl animals (a) is observed in the molecular layer (M) and in the hilus (H). In the pilocarpine-treated rats at 1 week (b) and 2 weeks (c), DA immunolabeling is strongly decreased in the inner molecular layer (IML) and in the H when compared with Ctl rats (a), whereas no difference is observed in pilocarpine-treated animals at 12 weeks (Chronic; (d)). The loss of labeling in these regions contrasted with the preservation of the levels of immunolabeling in the outer molecular layer (OML) and granule cell layer (G). Scale bars = 50 μm in ((a), (b), (c), and (d)). (e) Table showing the comparison of % optical density for drebrin A protein in H and IML between control and pilocarpine-treated animals at 1, 2, and 12 weeks. H: hilus; IML: inner molecular layer; P: probability, NS: not significant. Modified with permission from [39].
