|
Gene | Description of molecular events | Macropexophagy | Micropexophagy | Reference |
Pp | Hp | Pp |
|
ATG1 | Serine/threonine kinase required for PAS formation | ✓ | ✓ | ✓ | [42, 56, 57] |
ATG2 | Peripheral membrane protein required for Atg9 recycling | ✓ | | ✓ | [58] |
ATG3 | E2-like ubiquitin ligase that catalyzes lipidation of Atg8 | | | ✓ | [59] |
ATG4 | Protease that processes Atg8 as prerequisite for conjugation with phosphatidylethanolamine (PE) | | | ✓ | [60, 61] |
ATG6 | Subunit of PI3K complexes I and II | ✓ | | | [35] |
ATG7 | E1-(ubiquitin activating enzyme)-like protein involved in conjugation of Atg12-Atg5 and Atg8-PE conjugates | ✓ | | ✓ | [42, 62] |
ATG8 | Ubiquitin-like protein that is anchored to the expanded phagophore membrane in its processed and lipidated form, involved in phagophore membrane expansion | ✓ | ✓ | ✓ | [33, 60, 61] |
ATG9 | Transmembrane protein cycling between the PAS and a peripheral compartment | ✓ | | ✓ | [57, 63] |
ATG11 | Coiled-coil adaptor protein that interacts with the core machinery and known receptors for selective autophagy | ✓ | ✓ | ✓ | [64] |
ATG16 | Essential component of the Atg12-Atg5-Atg16 complex | (✓) | | ✓ | [42] |
ATG17 | Scaffold protein that is responsible for PAS organization | ✓ | | ✓ | [34] |
ATG18 | PtdIns3P-binding protein whose localization is dependent Atg9 and PtdIns-3P; recruits Atg2 and needed for Atg9 recycling | ✓ | | ✓ | [65, 66] |
ATG21 | WD40 protein with phosphoinositide binding domain that is involved in pexophagosome formation | | ✓ | | [67] |
ATG24 | Sorting nexin protein involved in fusion events with the vacuole | ✓ | | ✓ | [33] |
ATG25 | Coiled-coil protein that co-localizes with Atg11 at the PAS, required for macropexophagy | | ✓ | | [39] |
ATG26 | Sterol glucosyltransferase that plays a role in phagophore membrane expansion | ✓ | | ✓ | [44, 46, 68] |
ATG28 | Coiled-coil protein required for peroxisome sequestration during micropexophagy and vacuole fusion of pexophagosomes in macropexophagy | ✓ | | ✓ | [69] |
ATG30 | Pexophagy receptor that interacts with peroxins, Pex3 and Pex14, and adaptor proteins, Atg11 and Atg17 | ✓ | | ✓ | [34] |
ATG35 | Localizes to the perinuclear structure; regulates MIPA formation and interacts with Atg28 and Atg17 | | | ✓ | [43] |
GCN1-4 | Involved in general amino acid control | | | ✓ | [42] |
Sar1 | Sec protein required for MIPA and proper pexophagosome formation | | ✓ | ✓ | [70] |
PEP4 | Vacuolar protease | | | ✓ | [60] |
PEX3 | PMP peroxin required for peroxisome biogenesis and for recruitment of pexophagy receptor | ✓ | ✓ | ✓ | [34, 71, 72] |
PEX14 | PMP peroxin required for peroxisome biogenesis and for recruitment of pexophagy receptor | ✓ | ✓ | ✓ | [34, 73] |
PIK1 | PtdIns-4-kinase required for MIPA formation | | | ✓ | [46] |
PFK1 | Subunit of phosphofructokinase complex | | | ✓ | [62] |
TUP1 | Transcriptional repressor | ✓ | | | [74] |
VAC8 | N-myristoylated armadillo-repeat protein of the vacuolar membrane, required for VSM formation | | | ✓ | [75, 76] |
VAM7 | SNARE protein that is involved in vacuolar fusion events with the phagophore membrane | | ✓ | | [45] |
VPS15 | Regulatory subunit of PI3K | ✓ | ✓ | ✓ | [42, 77] |
VPS34 | Phosphatidylinositol-3-kinase (PI3K) | ✓ | ✓ | ✓ | [36, 78] |
YPT7 | Rab GTPase involved in phagophore membrane fusion | ✓ | ✓ | ✓ | [71, 79] |
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