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International Journal of Cell Biology
Volume 2012 (2012), Article ID 594681, 10 pages
http://dx.doi.org/10.1155/2012/594681
Review Article

Nasopharyngeal Carcinoma Signaling Pathway: An Update on Molecular Biomarkers

1Graduate Program in Molecular Medicine, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand
2Department of Biology, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand

Received 30 September 2011; Revised 20 December 2011; Accepted 20 December 2011

Academic Editor: R. Seger

Copyright © 2012 Warut Tulalamba and Tavan Janvilisri. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Nasopharyngeal carcinoma (NPC) is an uncommon cancer, which has a distinctive ethnic and geographic distribution. Etiology of NPC is considered to be related with a complex interaction of environmental and genetic factors as well as Epstein-Barr virus infection. Since NPC is located in the silent painless area, the disease is usually therefore diagnosed at the advanced stages; hence early detection of NPC is difficult. Furthermore, understanding in molecular pathogenesis is still lacking, pondering the identification of effective prognostic and diagnostic biomarkers. Dysregulation of signaling molecules in intracellular signal transduction, which regulate cell proliferation, apoptosis, and adhesion, underlines the basis of NPC pathogenesis. In this paper, the molecular signaling pathways in the NPC are discussed for the holistic view of NPC development and progression. The important insights toward NPC pathogenesis may offer strategies for identification of novel biomarkers for diagnosis and prognosis.