Table 1: Overview of KSHV miRNAs regulatory functions and targets.

FunctionsKSHV miRNAsValidated targetsReferences

KSHV entrymiR-K12-1[20]
miR-K12-9[20]
miR-K12-11BACH-1[20, 22, 23]

Induction of reactive nitrogen species (RNS)miR-K12-1, 9 and 11[20]

Endothelial cell reprogrammingmiR-K12-6 and 11MAF[24]

KSHV gene expressionmiR-K12-7RTA[37]
miR-K12-9RTA/BCLAF1[38, 39]
miR-K12-4Rbl2[40]
miR-K12-1IκBα[41]
miR-K12-3Nuclear factor I/B[42]
miR-K12-5BCLAF1[39]
miR-K12-11IKKε[43]
miR-K12-10 and 12[18]

Cytokine secretionmiR-K12-3 and 7[44]
miR-K12-11C/EBPβ[45]
miR-K12-10TWEAKR[46]

Immune escapemiR-K12-7MICB[47]

Cell survivalmiR-K12-10TWEAKR[46]
miR-K12-1p21[48]