Journal Menu
- About this Journal
- Abstracting and Indexing
- Aims and Scope
- Article Processing Charges
- Articles in Press
- Author Guidelines
- Bibliographic Information
- Citations to this Journal
- Contact Information
- Editorial Board
- Editorial Workflow
- Free eTOC Alerts
- Publication Ethics
- Reviewers Acknowledgment
- Submit a Manuscript
- Subscription Information
- Table of Contents
International Journal of Cell Biology
Volume 2012 (2012), Article ID 672462, 9 pages
doi:10.1155/2012/672462
Research Article
Distinct MicroRNA Subcellular Size and Expression Patterns in Human Cancer Cells
1Laboratory of Bioinformation and Noncoding RNA and Center for Systems Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
2Graduate University of Chinese Academy of Sciences, Beijing 100080, China
Received 27 July 2011; Accepted 9 November 2011
Academic Editor: Ivana De La Serna
Copyright © 2012 Beibei Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Linked References
- G. A. Calin and C. M. Croce, “MicroRNA signatures in human cancers,” Nature Reviews Cancer, vol. 6, no. 11, pp. 857–866, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- M. Fabbro and B. R. Henderson, “Regulation of tumor suppressors by nuclear-cytoplasmic shuttling,” Experimental Cell Research, vol. 282, no. 2, pp. 59–69, 2003. View at Publisher · View at Google Scholar
- L. J. Terry, E. B. Shows, and S. R. Wente, “Crossing the nuclear envelope: hierarchical regulation of nucleocytoplasmic transport,” Science, vol. 318, no. 5855, pp. 1412–1416, 2007. View at Publisher · View at Google Scholar · View at PubMed
- A. Esquela-Kerscher and F. J. Slack, “Oncomirs—microRNAs with a role in cancer,” Nature Reviews Cancer, vol. 6, no. 4, pp. 259–269, 2006. View at Publisher · View at Google Scholar · View at PubMed
- J. P. Morris and M. T. McManus, “Slowing down the Ras lane: miRNAs as tumor suppressors?” Science's STKE, vol. 2005, no. 297, p. e41, 2005.
- N. R. Smalheiser, “Regulation of mammalian microRNA processing and function by cellular signaling and subcellular localization,” Biochimica et Biophysica Acta, vol. 1779, no. 11, pp. 678–681, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- G. Meister and T. Tuschl, “Mechanisms of gene silencing by double-stranded RNA,” Nature, vol. 431, no. 7006, pp. 343–349, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- K. Chen and N. Rajewsky, “The evolution of gene regulation by transcription factors and microRNAs,” Nature Reviews Genetics, vol. 8, no. 2, pp. 93–103, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- A. G. Seto, R. E. Kingston, and N. C. Lau, “The coming of age for piwi proteins,” Molecular Cell, vol. 26, no. 5, pp. 603–609, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- A. A. Aravin, R. Sachidanandam, A. Girard, K. Fejes-Toth, and G. J. Hannon, “Developmentally regulated piRNA clusters implicate MILI in transposon control,” Science, vol. 316, no. 5825, pp. 744–747, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- A. A. Aravin and D. Bourc'his, “Small RNA guides for de novo DNA methylation in mammalian germ cells,” Genes and Development, vol. 22, no. 8, pp. 970–975, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- D. P. Bartel, “MicroRNAs: genomics, biogenesis, mechanism, and function,” Cell, vol. 116, no. 2, pp. 281–297, 2004. View at Publisher · View at Google Scholar · View at Scopus
- L. Ma, J. Teruya-Feldstein, and R. A. Weinberg, “Tumour invasion and metastasis initiated by microRNA-10b in breast cancer,” Nature, vol. 449, no. 7163, pp. 682–688, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- K. V. Morris, S. W. L. Chan, S. E. Jacobsen, and D. J. Looney, “Small interfering RNA-induced transcriptional gene silencing in human cells,” Science, vol. 305, no. 5688, pp. 1289–1292, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- H. Kawasaki and K. Taira, “Induction of DNA methylation and gene silencing by short interfering RNAs in human cells,” Nature, vol. 431, no. 7005, pp. 211–217, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- K. M. Brown, C. Y. Chu, and T. M. Rana, “Target accessibility dictates the potency of human RISC,” Nature Structural and Molecular Biology, vol. 12, no. 5, pp. 469–470, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- L. Weinmann, J. Höck, T. Ivacevic et al., “Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs,” Cell, vol. 136, no. 3, pp. 496–507, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- H. W. Hwang, E. A. Wentzel, and J. T. Mendell, “A hexanucleotide element directs microRNA nuclear import,” Science, vol. 315, no. 5808, pp. 97–100, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- S. Y. Berezhna, L. Supekova, F. Supek, P. G. Schultz, and A. A. Deniz, “siRNA in human cells selectively localizes to target RNA sites,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 20, pp. 7682–7687, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- R. D. Morin, M. D. O'Connor, M. Griffith et al., “Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells,” Genome Research, vol. 18, no. 4, pp. 610–621, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- Abcam, http://www.abcam.com/index.html?pageconfig=resource&rid=11473.
- UCSC, http://hgdownload.cse.ucsc.edu/downloads.html.
- The European ribosomal RNA database, http://www.psb.ugent.be/rRNA/index.html.
- GtRNAdb, http://lowelab.ucsc.edu/GtRNAdb/.
- piRNABank, http://pirnabank.ibab.ac.in/.
- NONCODE, http://www.noncode.org/.
- L. P. Lim, M. E. Glasner, S. Yekta, C. B. Burge, and D. P. Bartel, “Vertebrate microRNA genes,” Science, vol. 299, no. 5612, p. 1540, 2003. View at Publisher · View at Google Scholar · View at PubMed
- R. J. Taft, E. A. Glazov, N. Cloonan et al., “Tiny RNAs associated with transcription start sites in animals,” Nature Genetics, vol. 41, no. 5, pp. 572–578, 2009. View at Publisher · View at Google Scholar · View at PubMed
- T. Watanabe, Y. Totoki, A. Toyoda et al., “Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes,” Nature, vol. 453, no. 7194, pp. 539–543, 2008. View at Publisher · View at Google Scholar · View at PubMed
- O. H. Tam, A. A. Aravin, P. Stein et al., “Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes,” Nature, vol. 453, no. 7194, pp. 534–538, 2008. View at Publisher · View at Google Scholar · View at PubMed
- A. Azuma-Mukai, H. Oguri, T. Mituyama et al., “Characterization of endogenous human Argonautes and their miRNA partners in RNA silencing,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 23, pp. 7964–7969, 2008. View at Publisher · View at Google Scholar · View at PubMed
- I. Satzger, A. Mattern, U. Kuettler et al., “MicroRNA-15b represents an independent prognostic parameter and is correlated with tumor cell proliferation and apoptosis in malignant melanoma,” International Journal of Cancer, vol. 126, no. 11, pp. 2553–2562, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- A. Navarro, T. Diaz, A. Martinez et al., “Regulation of JAK2 by miR-135a: prognostic impact in classic Hodgkin lymphoma,” Blood, vol. 114, no. 14, pp. 2945–2951, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- S. F. Tavazoie, C. Alarcón, T. Oskarsson et al., “Endogenous human microRNAs that suppress breast cancer metastasis,” Nature, vol. 451, no. 7175, pp. 147–152, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- Z. Földes-Papp, K. König, H. Studier et al., “Trafficking of mature miRNA-122 into the nucleus of live liver cells,” Current Pharmaceutical Biotechnology, vol. 10, no. 6, pp. 569–578, 2009. View at Publisher · View at Google Scholar
- J. C. Ritland Politz, E. M. Hogan, and T. Pederson, “MicroRNAs with a nucleolar location,” RNA, vol. 15, no. 9, pp. 1705–1715, 2009. View at Publisher · View at Google Scholar · View at PubMed
- J. S. Mattick, P. P. Amaral, M. E. Dinger, T. R. Mercer, and M. F. Mehler, “RNA regulation of epigenetic processes,” BioEssays, vol. 31, no. 1, pp. 51–59, 2009. View at Publisher · View at Google Scholar · View at PubMed
- A. Bashirullah, R. L. Cooperstock, and H. D. Lipshitz, “Rna localization in development,” Annual Review of Biochemistry, vol. 67, pp. 335–394, 1998. View at Publisher · View at Google Scholar · View at PubMed
- A. A. Aravin, R. Sachidanandam, D. Bourc'his et al., “A piRNA pathway primed by individual transposons is linked to De Novo DNA methylation in mice,” Molecular Cell, vol. 31, no. 6, pp. 785–799, 2008. View at Publisher · View at Google Scholar · View at PubMed