Mitochondrial Dynamics in Cancer and Neurodegenerative and Neuroinflammatory Diseases

Table 1

Mitochondrial dynamics and cancer.

Pathology	Proteins involved (expression level)	Mitochondrial phenotype	Mechanisms of pathophysiology involving mitochondria
Different types of tumors	MFN1, MFN2, OPA1 ↓↓ DRP1, FIS1 ↑↑	Fragmentation.	Inhibition of TCA cycle and oxidative phosphorylation, mitochondrial membrane permeabilization; fission accompanied by ROS production, polarization and chemotaxis of lymphocytes and tumoral cells [42–45].