Review Article
Mitochondrial Dynamics in Cancer and Neurodegenerative and Neuroinflammatory Diseases
Table 3
Mitochondrial dynamics and neuroinflammatory and autoimmune diseases.
| Pathology | Proteins involved (expression level and/or mutation) | Mitochondrial phenotype | Mechanisms of pathophysiology involving mitochondria |
| Multiple sclerosis | OPA1 mutation | Fragmentation. | Reduction of respiratory rates with lower ATP production [139, 140]. |
| Type 1 diabetes | OPA1 ↓↓ DRP1 ↑↑ PHBs mutation | Fragmentation, disruption of cristae structure. | Alteration in OPA1 processing in β-cells in the pancreas and coronary endothelial cells from diabetic animals [141, 142]. |
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