- About this Journal
- Abstracting and Indexing
- Aims and Scope
- Article Processing Charges
- Articles in Press
- Author Guidelines
- Bibliographic Information
- Citations to this Journal
- Contact Information
- Editorial Board
- Editorial Workflow
- Free eTOC Alerts
- Publication Ethics
- Reviewers Acknowledgment
- Submit a Manuscript
- Subscription Information
- Table of Contents
International Journal of Cell Biology
Volume 2012 (2012), Article ID 737421, 9 pages
Formulation Changes Affect Material Properties and Cell Behavior in HA-Based Hydrogels
1Department of Bioengineering, University of Utah, 36 S. Wasatch Drive, Rm. 3100, Salt Lake City, UT 84112, USA
2SentrX Animal Care, Inc., 615 Arapeen Drive, Suite 110, Salt Lake City, UT 84108, USA
Received 10 September 2012; Accepted 2 November 2012
Academic Editor: Kaushik Chatterjee
Copyright © 2012 Thomas Lawyer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- M. T. Longaker, N. S. Adzick, J. L. Hall et al., “Studies in fetal wound healing, VII. Fetal wound healing may be modulated by hyaluronic acid stimulating activity in amniotic fluid,” Journal of Pediatric Surgery, vol. 25, no. 4, pp. 430–433, 1990.
- J. R. E. Fraser, T. C. Laurent, and U. B. G. Laurent, “Hyaluronan: its nature, distribution, functions and turnover,” Journal of Internal Medicine, vol. 242, no. 1, pp. 27–33, 1997.
- B. P. Toole, “Hyaluronan in morphogenesis,” Journal of Internal Medicine, vol. 242, no. 1, pp. 35–40, 1997.
- W. Y. J. Chen and G. Abatangelo, “Functions of hyaluronan in wound repair,” Wound Repair and Regeneration, vol. 7, no. 2, pp. 79–89, 1999.
- E. A. Turley, P. W. Noble, and L. Y. W. Bourguignon, “Signaling properties of hyaluronan receptors,” The Journal of Biological Chemistry, vol. 277, no. 7, pp. 4589–4592, 2002.
- K. R. Taylor, J. M. Trowbridge, J. A. Rudisill, C. C. Termeer, J. C. Simon, and R. L. Gallo, “Hyaluronan fragments stimulate endothelial recognition of injury through TLR4,” The Journal of Biological Chemistry, vol. 279, no. 17, pp. 17079–17084, 2004.
- S. Kikuchi, C. T. Griffini, S. S. Wang, and D. M. Bissell, “Role of CD44 in epithelial wound repair: migration of rat hepatic stellate cells utilizes hyaluronic acid and CD44v6,” The Journal of Biological Chemistry, vol. 280, no. 15, pp. 15398–15404, 2005.
- D. D. Allison and K. J. Grande-Allen, “Review. Hyaluronan: a powerful tissue engineering tool,” Tissue Engineering, vol. 12, no. 8, pp. 2131–2140, 2006.
- G. D. Prestwich, “Simplifying the extracellular matrix for 3-D cell culture and tissue engineering: a pragmatic approach,” Journal of Cellular Biochemistry, vol. 101, no. 6, pp. 1370–1383, 2007.
- G. D. Prestwich, “Evaluating drug efficacy and toxicology in three dimensions: using synthetic extracellular matrices in drug discovery,” Accounts of Chemical Research, vol. 41, no. 1, pp. 139–148, 2008.
- G. D. Prestwich, “Hyaluronic acid-based clinical biomaterials derived for cell and molecule delivery in regenerative medicine,” Journal of Controlled Release, vol. 155, pp. 193–199, 2011.
- G. Yang, L. Espandar, N. Mamalis, and G. D. Prestwich, “A cross-linked hyaluronan gel accelerates healing of corneal epithelial abrasion and alkali burn injuries in rabbits,” Veterinary Ophthalmology, vol. 13, no. 3, pp. 144–150, 2010.
- G. Yang, G. D. Prestwich, and B. K. Mann, “Thiolated carboxymethyl hyaluronic acid-based biomaterials enhance wound healing in rats, dogs, and horses,” ISRN Veterinary Science, vol. 2011, Article ID 851593, 7 pages, 2011.
- N. E. Larsen, C. T. Pollak, K. Reiner, E. Leshchiner, and E. A. Balazs, “Hylan gel biomaterial: dermal and immunologic compatibility,” Journal of Biomedical Materials Research, vol. 27, no. 9, pp. 1129–1134, 1993.
- L. Hallén, C. Johansson, and C. Laurent, “Cross-linked hyaluronan (hylan B gel): a new injectable remedy for treatment of vocal fold insufficiency—an animal study,” Acta Oto-Laryngologica, vol. 119, no. 1, pp. 107–111, 1999.
- J. A. Burdick, C. Chung, X. Jia, M. A. Randolph, and R. Langer, “Controlled degradation and mechanical behavior of photopolymerized hyaluronic acid networks,” Biomacromolecules, vol. 6, no. 1, pp. 386–391, 2005.
- J. B. Leach and C. E. Schmidt, “Characterization of protein release from photocrosslinkable hyaluronic acid-polyethylene glycol hydrogel tissue engineering scaffolds,” Biomaterials, vol. 26, no. 2, pp. 125–135, 2005.
- S. Duflo, S. L. Thibeault, W. Li, X. Z. Shu, and G. D. Prestwich, “Vocal fold tissue repair in vivo using a synthetic extracellular matrix,” Tissue Engineering, vol. 12, no. 8, pp. 2171–2180, 2006.
- Y. Liu, S. Ahmad, X. Z. Shu, R. K. Sanders, S. A. Kopesec, and G. D. Prestwich, “Accelerated repair of cortical bone defects using a synthetic extracellular matrix to deliver human demineralized bone matrix,” Journal of Orthopaedic Research, vol. 24, no. 7, pp. 1454–1462, 2006.
- Y. Liu, X. Z. Shu, and G. D. Prestwich, “Osteochondral defect repair with autologous bone marrow-derived mesenchymal stem cells in an injectable, in situ, cross-linked synthetic extracellular matrix,” Tissue Engineering, vol. 12, no. 12, pp. 3405–3416, 2006.
- Y. Liu, X. Z. Shu, and G. D. Prestwich, “Tumor engineering: orthotopic cancer models in mice using cell-loaded, injectable, cross-linked hyaluronan-derived hydrogels,” Tissue Engineering, vol. 13, no. 5, pp. 1091–1101, 2007.
- X. Z. Shu, K. Ghosh, Y. Liu et al., “Attachment and spreading of fibroblasts on an RGD peptide-modified injectable hyaluronan hydrogel,” Journal of Biomedical Materials Research A, vol. 68, no. 2, pp. 365–375, 2004.
- K. Ghosh, X. D. Ren, X. Z. Shu, G. D. Prestwich, and R. A. F. Clark, “Fibronectin functional domains coupled to hyaluronan stimulate adult human dermal fibroblast responses critical for wound healing,” Tissue Engineering, vol. 12, no. 3, pp. 601–613, 2006.
- J. L. Vanderhooft, M. Alcoutlabi, J. J. Magda, and G. D. Prestwich, “Rheological properties of cross-linked hyaluronan-gelatin hydrogels for tissue engineering,” Macromolecular Bioscience, vol. 9, no. 1, pp. 20–28, 2009.
- J. W. Gunn, S. D. Turner, and B. K. Mann, “Adhesive and mechanical properties of hydrogels influence neurite extension,” Journal of Biomedical Materials Research A, vol. 72, no. 1, pp. 91–97, 2005.
- J. L. Vanderhooft, B. K. Mann, and G. D. Prestwich, “Synthesis and characterization of novel thiol-reactive poly(ethylene glycol) cross-linkers for extracellular-matrix-mimetic biomaterials,” Biomacromolecules, vol. 8, no. 9, pp. 2883–2889, 2007.
- B. Jeong, Y. H. Bae, and S. W. Kim, “Thermoreversible gelation of PEG-PLGA-PEG triblock copolymer aqueous solutions,” Macromolecules, vol. 32, no. 21, pp. 7064–7069, 1999.
- B. K. Mann, A. S. Gobin, A. T. Tsai, R. H. Schmedlen, and J. L. West, “Smooth muscle cell growth in photopolymerized hydrogels with cell adhesive and proteolytically degradable domains: synthetic ECM analogs for tissue engineering,” Biomaterials, vol. 22, no. 22, pp. 3045–3051, 2001.
- A. S. Rowlands, P. A. George, and J. J. Cooper-White, “Directing osteogenic and myogenic differentiation of MSCs: interplay of stiffness and adhesive ligand presentation,” American Journal of Physiology, vol. 295, no. 4, pp. C1037–C1044, 2008.
- T. M. Birkenmeier, J. J. McQuillan, E. D. Boedeker, W. S. Argraves, E. Ruoslahti, and D. C. Dean, “The α5β1 fibronectin receptor: characterization of the α5 gene promoter,” The Journal of Biological Chemistry, vol. 266, no. 30, pp. 20544–20549, 1991.
- B. K. Mann and S. D. Turner, “Glycoproteins and adhesion peptides: properties and biomedical applications,” in Renewable Resources for Functional Polymers and Biomaterials: Polysaccharides, Proteins and Polyesters, P. A. Williams, Ed., Royal Society of Chemistry, London, UK, 2011.
- A. S. G. Curtis and J. V. Forrester, “The competitive effects of serum proteins on cell adhesion,” Journal of Cell Science, vol. 71, pp. 17–35, 1984.
- G. E. Davis, “Affinity of integrins for damaged extracellular matrix: α(v)β3 binds to denatured collagen type I through RGD sites,” Biochemical and Biophysical Research Communications, vol. 182, no. 3, pp. 1025–1031, 1992.
- M. H. Zaman, “Understanding the molecular basis for differential binding of integrins to collagen and gelatin,” Biophysical Journal, vol. 92, no. 2, pp. L17–L19, 2007.
- S. Johansson, G. Svineng, K. Wennerberg, A. Armulik, and L. Lohikangas, “Fibronectin-integrin interactions,” Frontiers in Bioscience, vol. 2, pp. d126–d146, 1997.
- T. Yeung, P. C. Georges, L. A. Flanagan et al., “Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion,” Cell Motility and the Cytoskeleton, vol. 60, no. 1, pp. 24–34, 2005.
- T. S. Panetti, D. F. Hannah, C. Avraamides et al., “Extracellular matrix molecules regulate endothelial cell migration stimulated by lysophosphatidic acid,” Journal of Thrombosis and Haemostasis, vol. 2, no. 9, pp. 1645–1656, 2004.
- M. Kubo, R. A. F. Clark, A. B. Katz et al., “Transduction of β3 integrin subunit cDNA confers on human keratinocytes the ability to adhere to gelatin,” Archives of Dermatological Research, vol. 299, no. 1, pp. 13–24, 2007.
- I. A. Potapova, I. S. Cohen, and S. V. Doronin, “Von willebrand factor increases endothelial cell adhesiveness for human mesenchymal stem cells by activating p38 mitogen-activated protein kinase,” Stem Cell Research and Therapy, vol. 1, no. 5, article 35, 2010.
- M. M. Martino, M. Mochizuki, D. A. Rothenfluh, S. A. Rempel, J. A. Hubbell, and T. H. Barker, “Controlling integrin specificity and stem cell differentiation in 2D and 3D environments through regulation of fibronectin domain stability,” Biomaterials, vol. 30, no. 6, pp. 1089–1097, 2009.
- G. C. Hunt, P. Singh, and J. E. Schwarzbauer, “Endogenous production of fibronectin is required for self-renewal of cultured mouse embryonic stem cells,” Experimental Cell Research, vol. 318, pp. 1820–1831, 2012.
- J. Veevers-Lowe, S. G. Ball, A. Shuttleworth, and C. M. Kielty, “Mesenchymal stem cell migration is regulated by fibronectin through a5b1-integrin-mediated activation of PDGFR-β and potentiation of growth factor signals,” Journal of Cell Science, vol. 124, no. 8, pp. 1288–1300, 2011.
- M. C. Markowski, A. C. Brown, and T. H. Barker, “Directing epithelial to mesenchymal transition through engineered microenvironments displaying orthogonal adhesive and mechanical cues,” Journal of Biomedical Materials Research A, vol. 100, pp. 2119–2127, 2012.
- G. D. Nicodemus, S. C. Skaalure, and S. J. Bryant, “Gel structure has an impact on pericellular and extracellular matrix deposition, which subsequently alters metabolic activities in chondrocyte-laden PEG hydrogels,” Acta Biomaterialia, vol. 7, no. 2, pp. 492–504, 2011.