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International Journal of Cell Biology
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International Journal of Cell Biology
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2012
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Article
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Fig 1
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Review Article
Autophagy in Pancreatic Cancer
Figure 1
Hypoxia induces autophagy. Hypoxia activates HIF-1
α
which in turn induces expression of the BH3-containing proteins BNIP3 and BNIP3L to compete with Beclin 1 for its interaction with Bcl2. As a consequence Beclin 1 is released to induce autophagy.