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International Journal of Cell Biology
Volume 2012 (2012), Article ID 760498, 7 pages
http://dx.doi.org/10.1155/2012/760498
Review Article

Autophagy in Pancreatic Cancer

Parc Scientifique et Technologique de Luminy, Stress Cellulaire, INSERM U624, 163 avenue de Luminy, CP 915, 13288 Marseille Cedex 9, France

Received 1 August 2011; Accepted 13 October 2011

Academic Editor: G. S. Stein

Copyright © 2012 Daniel Grasso et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Pancreatic adenocarcinoma (PDAC) is a devastating disease with an extremely poor life expectancy and no effective treatment. Autophagy is a process of degradation of cytoplasmic component capable of recycling cellular components or eliminate specific targets. The presence of autophagy in PDAC has been demonstrated. However, the implicated cellular pathways are not fully understood and, more importantly, the role of autophagy in PDAC is matter of intensive debate. This review summarizes recently published data in an attempt to clarify the importance of autophagy in this disease and try to reconcile apparently contradictory results.