Zinc Protoporphyrin Upregulates Heme Oxygenase-1 in PC-3 Cells via the Stress Response Pathway
Figure 3
Effect of ZnPP on StRE1, StRE2, StRE3, StRE5, HSE, SREBP, and SP1 elements of human HO-1 promoter in PC-3 cells. PC-3 cells were transfected with enhancer-luciferase reporter plasmid harboring one of these elements, treated with 10 μM ZnPP for 48 h, and luciferase activities were determined as described in Section 2. Results were expressed as “Fold Induction” over vehicle (DMSO)-treated control of the corresponding responsive element (.). ; * compared with vehicle-treated control of the corresponding responsive element.
