Trimeric Tau Is Toxic to Human Neuronal Cells at Low Nanomolar Concentrations

Figure 3

Recombinant human tau (rhTau) monomeric and oligomeric species production and purification. rhTau 1N4R enriched with disulfide-mediated tau oligomers (lane 1) was used for the purification of monomeric, dimeric, and trimeric tau species (lanes 2–4), 2N4R purified monomeric, dimeric, and trimeric species (lanes 5–7).