Regulation of the Ras-MAPK and PI3K-mTOR Signalling Pathways by Alternative Splicing in Cancer

Figure 3

Pathways for transformation by SRSF1. SRSF1 is a transcriptional target of the c-myc protooncogene and can be phosphorylated by SRPK or CLK downstream to Akt. SRSF1 alters the splicing of BIM, BIN1, S6K1, and Mnk2 regulating the mTOR and MAPK pathways, increasing translation, and inhibiting apoptosis.