Alternative Splicing Regulation of Cancer-Related Pathways in Caenorhabditis elegans: An In Vivo Model System with a Powerful Reverse Genetics Toolbox

Table 1

Ras pathway components, regulators, interactors, and targets in C. elegans. Those marked with a √ produce 2 or more isoforms differing by at least 1 alternative exon (according to [4, 39]).

Ras pathway component/interactor
ark-1		lin-10
cdf-1	√	lin-25
cnk-1		lin-31
dab-1	√	lin-39	√
dpy-22		lin-45	√
dpy-23	√	lip-1
egl-5	√	lrp-1
egl-18		lst-1	√
egl-15	√	lst-2
egl-17		lst-3	√
egl-19	√	lst-4	√
egl-30	√	mek-2
elt-6		mpk-1/sur-1	√
eor-1		par-1	√
eor-2	√	ptp-2
gap-1		rom-1
gap-2	√	sem-4
gpa-5		sem-5
ksr-1		sli-1	√
ksr-2	√	soc-1
let-23	√	sos-1/let-341
let-60		sra-13	√
let-92		sur-2
let-756		sur-5
lin-1		sur-6
lin-2	√	sur-7	√
lin-3	√	sur-8/soc-2	√
lin-7		unc-101	√