Ewing Sarcoma Protein: A Key Player in Human Cancer

Figure 1

Domain structure of TET proteins: the N-terminal activation domain and the C-terminal nucleic acid binding domain of TET proteins are schematized: the SYGQ rich domain, RGG boxes, and the RNA binding domain (RBD), Cys2-Cys2 zinc finger (ZF). Below the scheme, the exons encoding each domain are indicated for EWS, FUS/TLS, and TAF15, respectively [17, 18]. In the upper part of the figure the proteins that have been described to interact with either the DNA activation domain or the nucleic acid binding domain of EWS are listed.