Ewing Sarcoma Protein: A Key Player in Human Cancer
Figure 2
Schematic representation of the cross-talk between the transcriptional and splicing machineries mediated by RNAPII, EWS, and YB-1. (a) In normal condition EWS associates with the preinitiation complex TFIID, with the RNAPII and with its target transcripts and associated genomic regions; once the transcription has started, EWS jumps on the nascent RNA promoting specific AS events. (b) Upon CPT treatment EWS dissociates from YB-1 and from the spliceosome [64]. Similarly, upon low intensity UV light irradiation EWS dissociates from active transcription sites and relocalizes to nucleoli [51]. As a result, EWS regulated AS events cannot occur [51, 64].
