Receptor-Mediated Endocytosis and Brain Delivery of Therapeutic Biologics

Figure 2

Ratio of the organ PS product for the HIRMAb-TNFR fusion protein, over the organ PS product for the TNFR:Fc fusion protein, is plotted for each organ. The ratio for brain is the mean of the values for frontal gray matter, frontal white matter, cerebellar gray matter, and cerebellar white matter, which varied between 22 and 37 (adapted and modified from Figure 8, [61]).