Receptor-Mediated Endocytosis and Brain Delivery of Therapeutic Biologics
Figure 3
(a) Polarized transmigration of FC5 across HCEC monolayers. Transport studies were initiated by adding 10 μg/mL FC5 to either apical (A to B) or basolateral (B to A) compartment and the amount of FC5 in the opposite compartment was determined after 30 min. (b) Sucrose distribution across the same HCEC monolayers was used as internal control for paracellular transport (adapted and modified from Figure 1, [69]).
