Endocan in Cancers: A Lesson from a Circulating Dermatan Sulfate Proteoglycan
Figure 3
Endocan is expressed by endothelial cells during neoangiogenesis. (a) Endocan-immunopositive endothelial cells are always observed in multilayered endothelium characteristic of tumor vessels of the high-grade gliomas also called glioblastoma. (b) In brain tumor, Endocan is detected by immunohistochemistry even in one isolated but activated endothelial cells as an early event of neoangiogenesis. (c) Endocan is expressed by activated endothelial cell from small and large vessels in ACTH adenoma (adrenocorticotropic hormone adenoma from the pituitary). (d) Endocan reactivity is also observed even in small vessels and sparse endothelial cells in GH adenoma of the pituitary. Courtesy from C. A. Maurage.
