Expression of Tra2β in Cancer Cells as a Potential Contributory Factor to Neoplasia and Metastasis

Table 1

Known prooncogenic splicing targets of SFRS1 (previously known as ASF/SF2).

Splicing target	Possible role in cancer cells	Reference
RON	Δexon11 splice isoform increases cell motility and metastasis	[21, 25]
BIN	BIN12a splice isoform encodes protein no longer able to bind Myc and acts as tumour suppressor	[21, 25]
MNK2	MNK2 13b splice isoform makes kinase which can phosphorylate EIF4E independent of MAP kinase activation	[21, 25]
S6K	Promotes oncogenic isoform of S6kinase which phosphorylates small subunit of ribosome	[21, 25]
MCL-1/BCL-X/CASPASE9	Promotes production of antiapoptotic mRNAs to result in cell survival	[63–65]