Clinical Significance of HER-2 Splice Variants in Breast Cancer Progression and Drug Resistance

Table 1

HER-2 spliced variants and their role in cancer.

HER-2 splice variant	Alternatively spliced event	Function in cancer	Reference
Δ16HER2		Able to homodimerise to activate oncogenic pathways.; Increased transforming capacity.; Associated with treatment resistance.	[32, 33, 36]
p100		Truncated inhibitor of tumour cell proliferation and oncogenic signalling.	[34]
Herstatin		Inhibitor of HER-2 which interferes with dimerisation and autophosphorylation.; Inhibits growth of transformed cells which overexpress HER2.	[30, 31]