Table 1: Prion model of induction described for neurodegenerative diseases.

DiseaseNormally folded protein
“Precursor”
Abnormally folded protein
“Prion form”
Protein aggregates detectedSeeding inoculumPrion-like propagation in mammalsReferences

CJD/scrapiePrPCPrPScPrPSc deposits plaquesVarious mammalian prions and recPrP fibrilsWT and Tg mice
Non-human primates
[32, 33, 3740]
[4550]

Alzheimer (AD)Amyloid precursor protein (APP)Amyloid beta peptides A Aβ plaquesHuman AD and Tg mice brain extracts
blood
Marmosets
TgAPP2576
TgAPP23, TgAPP/PS1
[5358]

TauopathiesTauTau aggregatesNeurofibrillary tangles (NFTs)Tg(HuTauP301S) brain extractsTg(wt Tau)[59, 60]

Parkinson (PD)α-Synucleinα-Synuclein aggregatesLewy bodiesHuman
preformed
α-Syn fibrils
(i) Fetal tissue grafts in human PD patients[61, 62]
(ii) Tg (α-SynA53T) and WT mice[63, 64]