Changes in the Distribution of the α3 Na⁺/K⁺ ATPase Subunit in Heterozygous Lurcher Purkinje Cells as a Genetic Model of Chronic Depolarization during Development

Figure 1

Confocal images of immunohistochemistry for the α3 isoform of Na/K pumps in the cerebellar cortex of wild type (A)–(C) and +/Lc mice (D)–(F) at P15. The cerebellar sections in (A)–(F) were double labeled for calbindin (red) and the α3 isoform (green) with overlaid images in (C) and (F). The white arrows in (E) and (F) indicate calbindin labeled +/Lc Purkinje cells with particularly intense α3 isoform immunostaining. The asterisks in (E) and (F) indicate α3 isoform labeling in the granule cell layer. Scale bars: 20 μm.

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