Interaction of typical 2-Cys Prxs with signaling molecules in the phosphorylation and acetylation networks. Prx1 and Prx2 interact directly or indirectly via ROS with the kinases/phosphatases and regulate their activation. In addition, the activities of these two Prxs are also controlled by phosphorylation and acetylation. Note that the Prx1 expression is known to be controlled by a transcription factor Nrf2 (nuclear factor E2-related factor 2) under oxidative stress condition.
