Mitochondrial DNA and Functional Investigations into the Radiosensitivity of Four Mouse Strains
Figure 4
Calcium-induced hepatic mitochondrial swelling in 4 mouse strains. Hepatic mitochondria from C57BL/6, BALB/c, and C57BL/6 × BALB/c F1 hybrid mice were isolated. Calcium concentrations of 75 μM with or without 200 nM CSA were used to induce mitochondrial permeability pore opening. The response of mitochondria to calcium overload was recorded in 10-second intervals with a 540 nM spectrometer. Parental background significantly influenced the response of offspring to calcium overload. CSA was found to have a significant inhibitory effect in C57BL/6 mice and the F1 hybrids.
