Regulated Hyaluronan Synthesis by Vascular Cells

Figure 3

Schematic representation of the regulation of HA synthesis by OGT in SMCs. In normal conditions HAS2 in plasma membrane is active but can be rapidly degraded in a 26 S proteasome dependent manner. In hyperglycemic condition or after glucosamine treatments, OGT catalyzes the O-GlcNAcylation of HAS2 serine 221 residue, which greatly stabilizes HAS2 favoring HA production.