HARE-Mediated Endocytosis of Hyaluronan and Heparin Is Targeted by Different Subsets of Three Endocytic Motifs

Figure 1

HARE CD mutants with different combinations of the four endocytic motifs. The diagram illustrates the various combinations of HARE CD motifs (M1, M2, M3, and M4) present (dark gray boxes) or deleted (light gray boxes with X) in the panel of stable HARE-CD variant cell lines used here. The single transmembrane domain (TMD, black box), C-terminal region (CT), and presence of the site-specific Y2519A mutation in M3 are indicated.