Effects of Activating Mutations on EGFR Cellular Protein Turnover and Amino Acid Recycling Determined Using SILAC Mass Spectrometry

Figure 2

Plot of EGFR turnover rate data from 33 experiments analyzed over a three-month period from A431 cell line. Data was acquired at time points from 0 to 72 hours and incorporation of new K or R was measured. A turnover half-life of 27.5 hours was calculated for WT EGFR.