Research Article

Effects of Activating Mutations on EGFR Cellular Protein Turnover and Amino Acid Recycling Determined Using SILAC Mass Spectrometry

Figure 4

Plot of EGFR turnover data from H3255 cell line showing the effects of no amino acid recycling ( = 1.0), at constant 52% ( = 0.48), and with a linear increase in recycling up to 24 hours ( = 1 − 2.1/100).