Epigenetic Contribution of High-Mobility Group A Proteins to Stem Cell Properties

Figure 3

Rb and E2F in CSCs. (a) Phosphorylated Rb dissociates from E2F that induces proliferation factors; (b) blocking of Rb CDK4/6 kinases prevents Rb phosphorylation and inactivates proliferation; (c) HMGA proteins inhibit CDK4/6 Rb kinases and block cycle repressing-factors: proliferation is reactivated. Symbols are the same as shown in Figure 1.

(a)

(b)

(c)