Metabolism and Cancer: Old and New Players

Call for Papers

Altered metabolism represents one of the oldest hallmarks clearly associated with cancer. Despite Warburg's pioneering observations, this area remains, however, quite unexplored and only very recently reevaluated.

Accumulating evidence supports unexpected crosstalks between metabolism and pathological alterations of complex biological processes leading to cancer. These processes include angiogenesis or immune responses. Bidirectional relationships are also emerging between mediators of metabolic processes and factors that regulate proliferation and death/survival of cancer cells. Besides, recent progress in scientific investigation methods allows us to delineate new forms of mutual regulation between the metabolic switch from oxidative phosphorylation to aerobic glycolysis occurring in most cancer cells and to study corresponding gene/protein expression patterns.

The main goal of this special issue is to discuss consolidated roles of old actors in cancer metabolism, to underline novel emerging mediators, and to propose new potential players. We also intend to highlight compounds affecting cancer susceptibility by potentially impacting metabolism. We aim at providing important mechanistic insights on the roles played by metabolism in the continuous dynamic interaction between cancer and its microenvironment potentially leading to new anticancer therapeutic targets.

We encourage original contributions or reviews focusing on the following topics. Potential topics include, but are not limited to:

• Crosstalk between metabolism, oncogenes, and cell proliferation
• Crosstalk between components of the metabolic and cell death machinery
• Stress response and prosurvival signals as modulators of metabolism
• Genetic and epigenetic control of cancer metabolism
• Tumor microenvironment and metabolism
• Metabolism and immune system functions in cancer
• Metabolism and tumor angiogenesis
• Therapeutic perspectives of targeting metabolism in cancer
• Impact of natural compounds on cancer metabolism

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/ijcb/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:

Lead Guest Editor

• Claudia Cerella, Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Fondation Recherche sur le Cancer et les Maladies du Sang, Hôpital Kirchberg, Luxembourg, Luxembourg

Guest Editors

• Marc Diederich, Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Fondation Recherche sur le Cancer et les Maladies du Sang, Hôpital Kirchberg, Luxembourg, Luxembourg
• Carine Michiels, Laboratory of Biochemistry and Cellular Biology (URBC), NAmur Research Institute for LIfe Science (NARILIS), FUNDP-University of Namur, Namur, Belgium
• Young-Joon Surh, Tumor Microenvironment Global Core Research Center, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea
• Roderick H. Dashwood, Cancer Chemoprotection Program, Linus Pauling Institute, 307 Linus Pauling Science Center, Oregon State University, Corvallis, OR 97331, USA