Mean Platelet Volume and Splenomegaly as Useful Markers of Subclinical Activity in Egyptian Children with Familial Mediterranean Fever: A Cross-Sectional Study
Table 2
Characteristics, clinical findings, and laboratory investigations of FMF patients stratified by the presence of splenomegaly ().
Variable
Patients with splenomegaly
Patients without splenomegaly
value
()
()
Male/female
21/22
29/25
0.7
Positive consanguinity
16 (37.2%)
15 (27.8%)
0.4
Family history of FMF
7 (16.3%)
7 (13%)
0.8
Age at time of study
8.74 ± 3.59
8.68 ± 3.29
0.9
Age at disease onset
4.42 ± 2.81
4.92 ± 2.68
0.4
Age at diagnosis
6.81 ± 3.33
6.58 ± 3.03
0.7
Duration between the disease onset and diagnosis
2.25 ± 1.93
1.63 ± 2.07
0.04
Frequency of attacks/month
3.44 ± 3.00
3.18 ± 2.90
0.7
Duration of attacks/day
2.14 ± 2.07
1.43 ± 1.50
0.02
Colchicine duration (years)
2.06 ± 1.86
1.93 ± 1.96
0.6
Adherence to colchicine
21 (48.8%)
35 (64.8%)
0.1
Abdominal pain
42 (97.7%)
54 (100%)
0.4
Fever
37 (86%)
50 (92.6%)
0.3
Arthralgia
34 (79.1%)
43 (79.6)
1
Chest pain
22 (51.2%)
45 (83.3%)
0.001
Myalgia
18 (41.9%)
20 (37%)
0.7
Arthritis
17 (39.5%)
15 (27.8%)
0.3
Convulsion
6 (14%)
1 (1.9%)
0.04
MPVa (fL)
9.01 ± 2.37
7.48 ± 1.94
0.001
ESRb (mm/h)
29.37 ± 20.19
32.32 ± 19.59
0.4
CRPc titer (mg/L)
13.77 ± 11.37
14.89 ± 13.28
0.5
Platelet count (×103/mm3)
312.58 ± 75.34
327.32 ± 83.01
0.4
TLCd (×103/mm3)
7.37 ± 3.23
7.79 ± 3.11
0.5
V726A allelic
16 (18.6%)
16 (14.8%)
0.5
M694I allelic
10 (11.6%)
16 (14.8%)
0.5
E148Q allelic
8 (9.3%)
14 (12.9%)
0.5
M694V allelic
8 (9.3%)
13 (12%)
0.6
M680I allelic
7 (8.1%)
9 (8.3%)
1
P369S allelic
0
1 (0.9%)
1
Quantitative data are represented as mean ± standard deviation, while qualitative data are represented as frequency (%). value < 0.05 is significant. aMPV: mean platelet volume; bESR: erythrocyte sedimentation rate; cCRP: C-reactive protein; dTLC: total leucocytic count.
