Diabetes Mellitus as Hub for Tuberculosis Infection: A Snapshot

Figure 4

Mechanisms involved in enhancing TB infection during DM: during MTB infection the host innate immunity activates macrophages which causes phagocytosis and activates cytokines. Under nondiabetic condition cytokines become activated leading to ROS generation subsequently killing MTB. Under diabetic condition due to immunocompromised state the alteration in cytokine release leads to the survival of MTB due to suppressed ROS generation.