A Retrospective Analysis of Polymer Selection Using Solvent Casting: Formulation and DoE Optimization of the Amorphous Solid Dispersion of Amoxicillin Trihydrate by a Spray Drying Method

Table 2

Evaluation of design batches.

Run	Percentage yield^∗ (Y1) (%)	Dissolution at 10 min^∗ (Y2) (%)	Angle of repose^∗ (Y3) (°)	Bulk density (gm/ml)	Tapped density (gm/ml)	Carr’s index (%)	Houser’s ratio	Inter particle porosity
	33.33 ± 1.56	44.88 ± 1.23	29.74 ± 0.50	0.222	0.250	11.20	1.126	0.509
	34.24 ± 2.34	51.82 ± 0.98	32.82 ± 0.34	0.222	0.250	11.20	1.126	0.509
	37.63 ± 1.68	61.09 ± 2.56	34.59 ± 0.12	0.250	0.285	12.28	1.140	0.492
	23.65 ± 1.34	52.52 ± 1.85	31.21 ± 0.22	0.250	0.285	12.28	1.140	0.492
	26.72 ± 3.21	61.98 ± 1.97	34.59 ± 0.27	0.250	0.285	12.28	1.140	0.492
	29.25 ± 2.57	65.00 ± 0.68	38.65 ± 0.24	0.250	0.285	12.28	1.140	0.492
	18.20 ± 1.09	63.22 ± 2.85	33.69 ± 0.39	0.222	0.250	11.20	1.126	0.509
	18.71 ± 2.10	73.82 ± 2.16	38.65 ± 0.28	0.250	0.285	12.28	1.140	0.492
	21.37 ± 1.28	74.95 ± 1.66	41.01 ± 0.51	0.250	0.285	12.28	1.140	0.492

n = 3 ± SD.