International Journal of Chemical Engineering / 2024 / Article / Tab 2 / Research Article
A Retrospective Analysis of Polymer Selection Using Solvent Casting: Formulation and DoE Optimization of the Amorphous Solid Dispersion of Amoxicillin Trihydrate by a Spray Drying Method Table 2 Evaluation of design batches.
Run Percentage yield∗ (Y1) (%) Dissolution at 10 min∗ (Y2) (%) Angle of repose∗ (Y3) (°) Bulk density (gm/ml) Tapped density (gm/ml) Carr’s index (%) Houser’s ratio Inter particle porosity 33.33 ± 1.56 44.88 ± 1.23 29.74 ± 0.50 0.222 0.250 11.20 1.126 0.509 34.24 ± 2.34 51.82 ± 0.98 32.82 ± 0.34 0.222 0.250 11.20 1.126 0.509 37.63 ± 1.68 61.09 ± 2.56 34.59 ± 0.12 0.250 0.285 12.28 1.140 0.492 23.65 ± 1.34 52.52 ± 1.85 31.21 ± 0.22 0.250 0.285 12.28 1.140 0.492 26.72 ± 3.21 61.98 ± 1.97 34.59 ± 0.27 0.250 0.285 12.28 1.140 0.492 29.25 ± 2.57 65.00 ± 0.68 38.65 ± 0.24 0.250 0.285 12.28 1.140 0.492 18.20 ± 1.09 63.22 ± 2.85 33.69 ± 0.39 0.222 0.250 11.20 1.126 0.509 18.71 ± 2.10 73.82 ± 2.16 38.65 ± 0.28 0.250 0.285 12.28 1.140 0.492 21.37 ± 1.28 74.95 ± 1.66 41.01 ± 0.51 0.250 0.285 12.28 1.140 0.492