Susceptibility to Dental Caries and the Salivary Proline-Rich Proteins

Figure 2

Major genes encoding the acidic proline-rich proteins. The genes are shown 5′– 3′. Dark or gray rectangles represent exons. The unfilled rectangles indicate untranslated portions of exons or whole exons which are upstream of the translational start (AUG) codon. Vertical double-pointing arrow indicates the position of the translation start codon in exon 1. Exons are numbered thereafter. The PRH1 gene shown is for alleles Pa and Pif. Db is encoded by the same structured gene containing an additional 63-base insert in exon 3. The two alleles of PRH2 encode separate proteins, Pr1 and Pr2. The transcripts were obtained by inserting the gene name at http://www.genecards.org/ and then selecting for the transcript diagram at ensembl.org. The transcripts are modified to read 5′–3′ and annotated.