Susceptibility to Dental Caries and the Salivary Proline-Rich Proteins

Figure 5

Allelic variations of PRB2 gene. Upper sequence is PRB2L from the Uniprot.org website. The secretion signal and two amino acids connecting the exon-encoded sequences are indicated in Figure 3 as described for Figure 4. Magenta (residues 41–51) indicates a split repeat sequence whose last 11 amino acids precede the 15 repeats of a 20-amino acid segment (Table 4). The sequences are indicated by alternating black and red colors. A green-colored amino acid (S) separates precedes the first and some later repeats. Magenta (residue 362–370) indicates the first 9 amino acids of the split sequence. Lower sequence indicates different allelic products. The first 17 residues of peptide IB-1 (purple) are encoded by exon2 and its downstream residues by exon 3. The products are color coded: IB-1, purple; IB-7, brown; Con1, purple; IB8c, blue; IB-4, green. Asterisk indicates R (CGA) mutated to UGA (stop) with truncation of the allele at IB-7 or IB4 [75] and is indicated by asterisks at the appropriate arginine residues. The amino acid numbering within each allele or each furin-cleaved segment of each allele is given in Table 4. Underlines indicate furin cleavage sites (Section 6).