Susceptibility to Dental Caries and the Salivary Proline-Rich Proteins

Table 2

All possible combinations of expressed PRH1 alleles. The three proteins encoded by the PRH1 locus are on the left two columns and the two proteins encoded by the PRH2 locus in Caucasians on the right two columns. Because this locus is expressed from both parental genes (12A and 12B), there are six possible protein (allelic) combinations of Pa, Pif, and Db and three possible combinations of Pr1 and Pr2. This gives a total of 18 possible combinations (polymorphisms) among individuals. A single Caucasian individual has one of the six combinations encoded by the PRH1 locus paired with one of the three combinations encoded by the PRH2 locus [9].

PRH1 locus^1		PRH2 locus^1
Chromosome  12A  Protein	Chromosome  12B  Protein	Chromosome  12A  Protein	Chromosome  12B  Protein
Db	Db	PRP-1	PRP-1
Db	Pa	PRP-1	PRP-2
Db	Pif	PRP-2	PRP-2
Pa	Pa
Pa	Pif
Pif	Pif

¹Total = 6 PRH1 allelic combinations X 3 PRH2 combinations = 18.