The Principal of Dynamic Contrast Enhanced MRI, the Method of Pharmacokinetic Analysis, and Its Application in the Head and Neck Region

Figure 5

A poor tumor response to CRT, with an Ohboshi and Shimosato classification of I. The analyses were performed using a proprietary software program (PRIDE software, Philips Healthcare, Eindhoven, The Netherlands). Pre-CRT (a–c), Gd-enhanced 𝑇₁ WI (a), 𝐾^trans map (b), 𝑣_𝑒 map (c), Post-CRT (d–f), Gd-enhanced 𝑇₁ WI (d), 𝐾^trans map (e), 𝑣_𝑒 map (f). The tumor ROIs are delineated in red (a, d). The pre-CRT 𝐾^trans was 0.13 and 𝐾^trans decreased after CRT with an average of 0.10. 𝑣_𝑒 decrease from 0.28 to 0.23.