A Comparative Evaluation of the Efficacy of Two Novel Desensitising Dentifrices

Table 1

Summary of change from baseline in efficacy measures within each treatment group; Dentifrice A = Sensodyne Multi Action Iso-Active, Dentifrice B = Colgate Sensitive Pro-Relief. *From ANCOVA model with the following factors: treatment, baseline VAS stratification value (for Schiff and Tactile analyses), number of air sensitive teeth (covariate), and baseline (covariate). ^aNegative values favour Dentifrice A. ^bPositive values favour Dentifrice A. Baseline values are raw means (SD).

Time point	Sensitivity parameter	Dentifrice A (𝑁=55)		Dentifrice B (𝑁=54)
		Adjusted mean; (95% CI) 𝑃 value*	% Change from; baseline	Adjusted mean; (95% CI) 𝑃 value*	% Change from; baseline
Baseline	VAS	74.3 (16.31)	—	74.2 (17.36)	—
	Schiff	2.6 (0.40)	—	2.5 (0.45)	—
	Tactile	13.0 (4.47)	—	12.9 (4.19)	—
Week 1	VAS^a	−8.4 (−13.5, −3.4)	11	−6.7 (−11.9, −1.5)	9
		0.0013		0.0115
	Schiff^a	−0.6 (−0.8, −0.4)	24	−0.6 (−0.8, −0.4)	25
		<0.0001		<0.0001
	Tactile^b	4.9 (1.4, 8.3)	38	4.4 (0.9, 7.9)	34
		0.0059		0.0137
Week 2	VAS^a	−20.5 (−26.7, −14.2)	28	−16.4 (−22.8, −10.1)	22
		<0.0001		<0.0001
	Schiff^a	−0.9 (−1.1, −0.8)	37	−0.9 (−1.1, −0.7)	35
		<0.0001		<0.0001
	Tactile^b	6.7 (2.7, 10.6)	51	6.9 (2.8, 10.9)	53
		0.0012		0.0011
Week 4	VAS^a	−24.3 (−31.6, −17.0)	33	−20.5 (−28.0, −13.1)	28
		<0.0001		<0.0001
	Schiff^a	−1.2 (−1.4, −1.0)	46	−1.1 (−1.3, −0.8)	42
		<0.0001		<0.0001
	Tactile^b	15.5 (10.4, 20.6) <0.0001	119	13.3 (8.1, 18.6) <0.0001	104
Week 8	VAS^a	−36.6 (−44.5, −28.6)	49	−33.2 (−41.6, −24.8)	45
		<0.0001		<0.0001
	Schiff^a	−1.6 (−1.8, −1.4)	61	−1.5 (−1.7, −1.3)	61
		<0.0001		<0.0001
	Tactile^b	22.1 (16.9, 27.2)	170	20.2 (14.8, 25.6)	157
		<0.0001		<0.0001