Genetic Association of MMP10, MMP14, and MMP16 with Dental Caries

Figure 1

Genetic association in adults and children samples for 3 MMP genes. Genetic association in samples of adults (a) and children (b) for 3 MMP genes. Negative log₁₀ transformed values are shown. Childhood samples: Center for Oral Health in Appalachia (COHRA1 (red)), Iowa Head Start (IHS (blue)), and Iowa Fluoride Study (IFS (purple)). Adult samples: Center for Oral Health in Appalachia (COHRA1 (red)), Dental Strategies Concentrating on Risk Evaluation (Dental SCORE (green)), Dental Registry and DNA Repository (DRDR (orange)), and Center for Education and Drug Abuse Research (CEDAR (yellow)). Circles represent white samples, and squares represent black samples. For children samples, white diamonds represent meta-analysis across all white childhood samples, and gray diamonds represent meta-analysis across all black and white childhood samples combined. Similarly, for adult samples, white diamonds represent meta-analysis across all white adult samples and gray diamonds represent meta-analysis across all black and white adult samples, combined. The dotted lines represent the threshold after adjustment for the number of independent single nucleotide polymorphisms within a gene. The physical location and directions of the genes are denoted by the blue arrows.

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(b)