Effects of Antimicrobial Photodynamic Therapy and Local Administration of Minocycline on Clinical, Microbiological, and Inflammatory Markers of Periodontal Pockets: A Pilot Study
Table 2
Changes in clinical parameters and bacterial levels after aPDT or local minocycline administration.
(a) Baseline
(b) 1 week after treatment
(c) 4 weeks after treatment
value
Between (a) and (b)
Between (a) and (c)
Between aPDT and MO groups
aPDT group
MO group
aPDT group
MO group
aPDT group
MO group
aPDT group
MO group
aPDT group
MO group
(a)
(b)
(c)
PD-treated sites (mm)
5.8 ± 1.0
5.4 ± 1.1
5.4 ± 1.3
4.7 ± 1.3
4.8 ± 1.4
4.3 ± 1.4
0.0569
0.0024†
0.0003†
0.0001†
0.1417
0.045
0.1581
CAL-treated sites (mm)
6.8 ± 1.6
6.1 ± 1.8
6.2 ± 1.8
5.4 ± 1.6
5.8 ± 1.8
5.1 ± 1.7
0.0254
0.004†
0.0005†
0.0022†
0.1809
0.1275
0.2443
BOP-treated sites (% positive)
76.7 ± 43.0
80.0 ± 40.7
66.7 ± 47.9
43.3 ± 50.4
40.0 ± 49.8
46.7 ± 50.7
0.4054
0.0023†
0.0116†
0.0039†
0.756
0.0717
0.6054
Total bacteria (log10)
4.72 ± 1.05
4.53 ± 0.87
4.68 ± 0.76
4.16 ± 0.53
4.57 ± 1.11
4.17 ± 0.67
0.8015
0.1228
0.4771
0.2101
0.3826
0.0531
0.0805
P. gingivalis (log10)
2.63 ± 1.62
2.68 ± 1.44
2.42 ± 1.68
0.61 ± 0.41
2.28 ± 1.79
1.12 ± 1.31
0.8753
0.0033†
0.3574
0.0053†
0.9331
0.0006
0.0548
P. gingivalis ratio (%)
2.70 ± 3.47
5.80 ± 12.11
3.59 ± 4.39
0.01 ± 0.02
3.20 ± 4.48
1.20 ± 3.49
0.4328
0.0022†
0.7213
0.0414
0.6153
0.0006
0.0518
T. forsythia (log10)
3.01 ± 1.50
2.89 ± 1.31
2.89 ± 1.54
1.45 ± 0.87
2.87 ± 1.51
2.03 ± 1.23
0.7986
0.0032†
0.5627
0.064
0.5883
0.0088
0.0915
T. forsythia ratio (%)
4.08 ± 3.58
4.27 ± 4.60
4.75 ± 4.62
0.77 ± 1.03
4.51 ± 4.30
2.62 ± 4.70
0.7537
0.0019†
0.7532
0.2719
0.9834
0.0083
0.1694
Data are presented as mean ± standard deviation. Ratio was defined as (individual bacteria count)/(total bacterial count). Intergroup comparison between groups: Mann–Whitney U test (). Intragroup comparisons: Wilcoxon signed-rank test with the Bonferroni correction for multiple comparisons (†).
