Research Article
Mathematical Modeling of the Adaptive Immune Responses in the Early Stage of the HBV Infection
Table 1
Parameters, their symbols, and default values used in Model (
3).
| Parameters | Meaning | Value | References |
| | Maximum hepatocyte growth rate | ≤1.0 day−1 | [23, 24] | | Hepatocyte carrying capacity | 2 × 1011 cells | [25] | | Rate of virion infection of hepatocytes | 3.6 × 10−5–1.8 × 10−3 cells virion−1 day−1 | [26] | | Time delay | 1 day | [27, 28] | | Normal death rate for hepatocytes | .0039 day−1 | [27, 28] | | Infected hepatocyte death rate | 0.0693–0.00693 day−1 | [25] | | Clearance rate of infection | 7 ± 1.7 × 10−4 ml/cell day−1 | [29] | | Number of free viruses produced by infected cells | 480 | [12, 13] | | Free virion half-life | 0.67 day−1 | [30] | | Neutralization rate of virion and antibodies | 10−10–10−12 ml day−1 | [31] | | Activation rate of B-cells | 1.38 × 10−2–10−4 day−1 | [31] | | Death rate of B-cells | 0.03–0.1 day−1 | [31] | | Activation rate of CTL cells | 4.4 ± 1.5 × 10−7 ml cell−1 day−1 | [29] | | Death rate of CTL cells | 0.5 day−1 | [32] |
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