International Journal of Endocrinology
Volume 2009 (2009), Article ID 391284, 6 pages
doi:10.1155/2009/391284
Clinical Study
Use of the Dexamethasone-Corticotrophin Releasing Hormone Test to Assess Hypothalamic-Pituitary-Adrenal Axis Function in Rheumatoid Arthritis
1The Academic Rheumatology Unit, University of Bristol, UK
2Welcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, UK
Received 7 February 2009; Revised 6 June 2009; Accepted 21 July 2009
Academic Editor: Andre Marette
Copyright © 2009 Eman A. Hasan et al. This is an open access article distributed under the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Linked References
- A. T. Masi, J. W. J. Bijlsma, I. C. Chikanza, C. Pitzalis, and M. Cutolo, “Neuroendocrine, immunologic, and microvascular systems interactions in rheumatoid arthritis: physiopathogenetic and therapeutic perspectives,” Seminars in Arthritis and Rheumatism, vol. 29, no. 2, pp. 65–81, 1999. View at Publisher · View at Google Scholar · View at Scopus
- Y. T. Konttinen, P. Kemppinen, M. Segerberg, et al., “Peripheral and spinal neural mechanisms in arthritis, with particular reference to treatment of inflammation and pain,” Arthritis and Rheumatism, vol. 37, no. 7, pp. 965–982, 1994. View at Publisher · View at Google Scholar · View at Scopus
- G. P. Chrousos and P. W. Gold, “The concepts of stress and stress system disorders: overview of physical and behavioral homeostasis,” Journal of the American Medical Association, vol. 267, no. 9, pp. 1244–1252, 1992. View at Publisher · View at Google Scholar · View at Scopus
- G. P. Chrousos, “Regulation and dysregulation of the hypothalamic-pituitary-adrenal axis. The corticotropin-releasing hormone perspective,” Endocrinology and Metabolism Clinics of North America, vol. 21, no. 4, pp. 833–858, 1992. View at Scopus
- R. H. Straub and M. Cutolo, “Involvement of the hypothalamic-pituitary-adrenal/gonadal axis and the peripheral nervous system in rheumatoid arthritis: viewpoint based on a systemic pathogenetic role,” Arthritis and Rheumatism, vol. 44, no. 3, pp. 493–507, 2001. View at Publisher · View at Google Scholar · View at Scopus
- H. O. Besedovsky and A. del Rey, “Immune-neuro-endocrine interactions: facts and hypotheses,” Endocrine Reviews, vol. 17, no. 1, pp. 64–102, 1996. View at Publisher · View at Google Scholar · View at Scopus
- G. Mastorakos, G. P. Chrousos, and J. S. Weber, “Recombinant interleukin-6 activates the hypothalamic-pituitary-adrenal axis in humans,” Journal of Clinical Endocrinology and Metabolism, vol. 77, no. 6, pp. 1690–1694, 1993. View at Publisher · View at Google Scholar · View at Scopus
- P. E. Sawchenko, T. Imaki, E. Potter, K. Kovács, J. Imaki, and W. Vale, “The functional neuroanatomy of corticotropin-releasing factor,” in Proceedings of the Ciba Foundation Symposium, vol. 172, pp. 5–21, 1993. View at Scopus
- I. C. Chikanza, P. Petrou, and G. Chrousos, “Perturbations of arginine vasopressin secretion during inflammatory stress: pathophysiologic implications,” Annals of the New York Academy of Sciences, vol. 917, pp. 825–834, 2000. View at Scopus
- D. S. Jessop and M. S. Harbuz, “A defect in cortisol production in rheumatoid arthritis: why are we still looking?” Rheumatology, vol. 44, no. 9, pp. 1097–1100, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- U. von Bardeleben and F. Holsboer, “Effect of age on the cortisol response to human corticotropin-releasing hormone in depressed patients treated with dexamethasone,” Biological Psychiatry, vol. 29, no. 10, pp. 1042–1050, 1991. View at Publisher · View at Google Scholar · View at Scopus
- J. Schmider, C.-H. Lammers, U. Gotthardt, M. Dettling, F. Holsboer, and I. J. E. Heuser, “Combined dexamethasone/corticotropin-releasing hormone test in acute and remitted manic patients, in acute depression, and in normal controls: I,” Biological Psychiatry, vol. 38, no. 12, pp. 797–802, 1995. View at Scopus
- M. S. Harbuz, E. Korendowych, D. S. Jessop, A. L. Crown, S. L. Lightman, and J. R. Kirwan, “Hypothalamo-pituitary-adrenal axis dysregulation in patients with rheumatoid arthritis after the dexamethasone/corticotrophin releasing factor test,” Journal of Endocrinology, vol. 178, no. 1, pp. 55–60, 2003. View at Publisher · View at Google Scholar · View at Scopus
- A. M. Huisman, A. A. van Everdingen, M. J. G. Wenting, et al., “Down regulation of glucocorticoid receptor in early-diagnosed rheumatoid arthritis,” Clinical and Experimental Rheumatology, vol. 20, no. 4, pp. 463–468, 2002. View at Scopus
- R. H. Derijk, M. J. M. Schaaf, G. Turner, et al., “A human glucocorticoid receptor gene variant that increases the stability of the glucocorticoid receptor β-isoform mRNA is associated with rheumatoid arthritis,” Journal of Rheumatology, vol. 28, no. 11, pp. 2383–2388, 2001. View at Scopus
- R. H. DeRijk, M. Schaaf, and E. R. de Kloet, “Glucocorticoid receptor variants: clinical implications,” Journal of Steroid Biochemistry and Molecular Biology, vol. 81, no. 2, pp. 103–122, 2002. View at Publisher · View at Google Scholar · View at Scopus
- S. Wüst, E. F. C. Van Rossum, I. S. Federenko, J. W. Koper, R. Kumsta, and D. H. Hellhammer, “Common polymorphisms in the glucocorticoid receptor gene are associated with adrenocortical responses to psychosocial stress,” Journal of Clinical Endocrinology and Metabolism, vol. 89, no. 2, pp. 565–573, 2004. View at Publisher · View at Google Scholar · View at Scopus
- D. H. Hellhammer, S. Wüst, and B. M. Kudielka, “Salivary cortisol as a biomarker in stress research,” Psychoneuroendocrinology, vol. 34, no. 2, pp. 163–171, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- D. S. Jessop and J. M. Turner-Cobb, “Measurement and meaning of salivary cortisol: a focus on health and disease in children,” Stress, vol. 11, no. 1, pp. 1–14, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- B. M. Kudielka, D. H. Hellhammer, and S. Wüst, “Why do we respond so differently? Reviewing determinants of human salivary cortisol responses to challenge,” Psychoneuroendocrinology, vol. 34, no. 1, pp. 2–18, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- P. Gallagher, M. M. Leitch, A. E. Massey, R. H. McAllister-Williams, and A. H. Young, “Assessing cortisol and dehydroepiandrosterone (DHEA) in saliva: effects of collection method,” Journal of Psychopharmacology, vol. 20, no. 5, pp. 643–649, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- C. C. Chryssanthopoulou, J. M. Turner-Cobb, A. Lucas, and D. Jessop, “Childcare as a stabilizing influence on HPA axis functioning: a reevaluation of maternal occupational patterns and familial relations,” Developmental Psychobiology, vol. 47, no. 4, pp. 354–368, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- D. S. Jessop, M. F. Dallman, D. Fleming, and S. L. Lightman, “Resistance to glucocorticoid feedback in obesity,” Journal of Clinical Endocrinology and Metabolism, vol. 86, no. 9, pp. 4109–4114, 2001. View at Publisher · View at Google Scholar · View at Scopus
- S. Ernestam, I. Hafström, S. Werner, K. Carlström, and B. Tengstrand, “Increased DHEAS levels in patients with rheumatoid arthritis after treatment with tumor necrosis factor antagonists: evidence for improved adrenal function,” Journal of Rheumatology, vol. 34, no. 7, pp. 1451–1458, 2007. View at Scopus
- E. M. Sternberg, M. N. Silverman, and G. Cizza, “The neuroendocrine system and rheumatoid arthritis: insights from anti-tumor necrosis factor- therapy,” Journal of Rheumatology, vol. 34, no. 7, pp. 1443–1445, 2007. View at Scopus
- M. S. Harbuz and D. S. Jessop, “Is there a defect in cortisol production in rheumatoid arthritis?” Rheumatology, vol. 38, no. 4, pp. 298–302, 1999. View at Publisher · View at Google Scholar · View at Scopus
- J. C. Dekkers, R. Geenen, G. L. R. Godaert, L. J. P. van Doornen, and J. W. J. Bijlsma, “Diurnal rhythm of salivary cortisol levels in patients with recent-onset rheumatoid arthritis,” Arthritis and Rheumatism, vol. 43, no. 2, pp. 465–467, 2000. View at Publisher · View at Google Scholar · View at Scopus
- A. M. M. Eijsbouts, F. H. J. van den Hoogen, R. F. J. M. Laan, A. R. M. M. Hermus, F. C. G. J. Sweep, and L. B. A. van de Putte, “Hypothalamic-pituitary-adrenal axis activity in patients with rheumatoid arthritis,” Clinical and Experimental Rheumatology, vol. 23, no. 5, pp. 658–664, 2005. View at Scopus
- J. Rovensky, R. Imrich, J. Koska, et al., “Cortisol elimination from plasma in premenopausal women with rheumatoid arthritis,” Annals of the Rheumatic Diseases, vol. 62, no. 7, pp. 674–676, 2003. View at Publisher · View at Google Scholar · View at Scopus
- J. M. Turner Cobb, A. Steptoe, L. Perry, and J. Axford, “Adjustment in patients with rheumatoid arthritis and their children,” Journal of Rheumatology, vol. 25, no. 3, pp. 565–571, 1998. View at Scopus
- J. L. Jensen, T. Uhlig, T. K. Kvien, and T. Axell, “Characteristics of rheumatoid arthritis patients with self-reported sicca symptoms: evaluation of medical, salivary and oral parameters,” Oral Diseases, vol. 3, no. 4, pp. 254–261, 1997. View at Scopus
- K. Moen, L. T. Bertelsen, S. Hellem, R. Jonsson, and J. G. Brun, “Salivary gland and temporomandibular joint involvement in rheumatoid arthritis: relation to disease activity,” Oral Diseases, vol. 11, no. 1, pp. 27–34, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- R. M. Nagler, F. Salameh, A. Z. Reznick, V. Livshits, and A. M. Nahir, “Salivary gland involvement in rheumatoid arthritis and its relationship to induced oxidative stress,” Rheumatology, vol. 42, no. 10, pp. 1234–1241, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- L. M. J. Helenius, J. H. Meurman, I. Helenius, et al., “Oral and salivary parameters in patients with rheumatic diseases,” Acta Odontologica Scandinavica, vol. 63, no. 5, pp. 284–293, 2005. View at Publisher · View at Google Scholar · View at Scopus
- J. G. Brun, T. M. Madland, and R. Jonsson, “A prospective study of sicca symptoms in patients with rheumatoid arthritis,” Arthritis Care and Research, vol. 49, no. 2, pp. 187–192, 2003. View at Scopus