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International Journal of Endocrinology
Volume 2010 (2010), Article ID 108641, 7 pages
http://dx.doi.org/10.1155/2010/108641
Research Article

Prolonged Sleep Restriction Affects Glucose Metabolism in Healthy Young Men

1Brain and Work Research Centre, Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, 00250 Helsinki, Finland
2Department of Physiology, Institute of Biomedicine, University of Helsinki, PO Box 63, 00014 Helsinki, Finland
3Centre of Expertise for Health and Work Ability, Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, 00250 Helsinki, Finland

Received 31 July 2009; Revised 13 November 2009; Accepted 10 February 2010

Academic Editor: Deborah Suchecki

Copyright © 2010 Wessel M. A. van Leeuwen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This study identifies the effects of sleep restriction and subsequent recovery sleep on glucose homeostasis, serum leptin levels, and feelings of subjective satiety. Twenty-three healthy young men were allocated to a control group (CON) or an experimental (EXP) group. After two nights of 8 h in bed (baseline, BL), EXP spent 4 h in bed for five days (sleep restriction, SR), followed by two nights of 8 h (recovery, REC). CON spent 8 h in bed throughout the study. Blood samples were taken after the BL, SR, and REC period. In EXP, insulin and insulin-to-glucose ratio increased after SR. IGF-1 levels increased after REC. Leptin levels were elevated after both SR and REC; subjective satiety remained unaffected. No changes were observed in CON. The observed increase of serum IGF-1 and insulin-to-glucose ratio indicates that sleep restriction may result in an increased risk to develop type 2 diabetes.